Context Vegetation is projected to continue to undergo major structural changes in coming decades due to land conversion and climate change, including widespread forest die-offs. These vegetation changes are important not only for their local or regional climatic effects, but also because they can affectclimate and subsequently vegetation in other regions or continents through ‘‘ecoclimate teleconnections’’. Objectives We propose that ecoclimate teleconnec- tions are a fundamental link among regions within and across continents, and are central to advancing large- scale macrosystems ecology. Methods and results We illustrate potential ecocli- mate teleconnections in a bounding simulation that assumes complete tree cover loss in western North America due to tree die-off, and which predicts subsequent drying and reduced net primary produc- tivity in other areas of North America, the Amazon and elsewhere. Central to accurately modeling such